Comm 100 3PM
16 October 2017
History of Insulin
SPECIFIC PURPOSE: To inform my audience the major historical developments of insulin.
CENTRAL IDEA: The vast improvement of insulin developed through the 19th, 20th, and 21st centuries.
ORGANIZATIONAL PATTERN: Chronological
Attention and interest: Who is she?
She's rather a very close friend of mine. Some may even say we look alike. Truthfully,
she's a friend who not only saved my life, but also the lives of many who are
diagnosed with diabetes. Her name is Insulin.
Reveal topic: Diabetes, a definition
provided by the U.S. National Library of Medicine, explained that it "is a
disease in which your blood glucose, or blood sugar, levels are too high." From
the early findings of diabetes, many human beings were brutally perished due to
an unknown cause—a disease that would turn an excruciating life
expectancy within three weeks said Jim Turner, a diabetes educator. The unknown
cause brought upon the discovery of insulin. Through the doctors and nurses
I've met in the hospital, they've explained that insulin is a hormone that
releases into the bloodstream in the body pertaining to the endocrine system,
where glands, or organs regulate blood sugar levels. Of December 2016, a
diabetic author Ginger Vieira, explained that approximately 57 million people
living with Type 1 diabetes are encountering death due to the unavailability of
insulin. Without the vital medication, one cannot sustain the ability to live.
Credibility and Goodwill: Although, as
an individual diagnosed with Type 1 diabetes for thirteen years, carrying
around an insulin pump since my childhood, I am educated with the fundamental
function of insulin with the aid of Dr. Vargas, my endocrinologist—a
doctor who specializes in restoring a patient's hormones. Additionally, I would
attend diabetic workshops and conventions whenever Rady Children's Hospital
provided me the opportunity. However, I have evermore ignited myself an
abundant curiosity as to where the origins of insulin begun and how insulin
improved throughout the centuries.
Preview statement: With this interest, I would like to share with you the significant findings of insulin throughout the 19th, 20th, and 21st centuries.
(transition: Let's start with the 19th century.)
I. The many vital
discoveries of insulin shed its light in the 19th century.
1869, Paul Langerhans stumbled on cells that produce insulin.
conducting a lab in the field of pathology, he came across the pancreatic
islets, or what is now named after his discovery, the 'Islets of Langerhans.'
(1) The 'Islets of
Langerhans' are tiny clusters of cells that disperse through the pancreas,
according to the Diabetes Research Institute Foundation.
(2) These pancreatic islets
contain beta cells.
(3) As explained by Diabetes.co.uk,
a health platform publishing daily information on managing diabetes, said "beta
cells are unique cells in the pancreas that produce, store and release the
(4) Additionally, a purpose
of an pancreas as provided by Columbia University Medical Center
explained that it is "an endocrine function that regulates blood sugar."
(5) However, the unknown
function of the islet discovered by Langerhans will remain a mystery until
another few years.
Langerhans made a remarkable contribution in the beginning of the vast
searchings for understanding diabetes, Bridget Montgomery, The Diabetes
Council publisher of the recent article "From Death to Life: The Discovery of
Insulin," stated that "it still took some time to understand the
functioning of the pancreas."
in 1889, the incredible study was expanded even further by a German
researcher, Oscar Minkowski and his partner, doctor Joseph von Mering.
researchers still had challenges as to where the sudden disease stumbled upon
and how to cure it; however, Minkowski and Mering made their scientific
(1) Both conducted an
experiment in which they removed the pancreas of a dog.
mentioned that the two doctors removed the pancreas from the body of the dog,
which resulted in the dog contracting diabetes.
(b) But she stated when the
doctors "surgically tied off the duct in which the pancreatic juices flowed,
the dog only developed some minor digestive issues, but not diabetes."
(c) Furthermore, not only
the function of the pancreas is to regulate blood sugar levels but to also aid
the digestive system.
(d) This discovery came to
one of the major significant events of history; the two skilled doctors who
unleashed an opening to understanding insulin.
the fact that, this was only the beginning of the incredible finding, many
people still struggled with the hardships of diabetes.
only way individuals could've adapted without the treatment was to enable a
strict diet and to wait patiently.
the longer a person waits without insulin, Centers for Disease Control and
Prevention acknowledged that "[w]hen there isn't enough insulin or cells
stop responding to insulin, too much blood sugar stays in [the] bloodstream,
which over time can cause serious health problems, such as heart disease,
vision loss, and kidney disease."
(Transition: Now that
I've shared the significant findings of insulin in the 19th century, let's move
on into the 20th century.)
II. The many vital
discoveries of insulin shed its light in the 20th century.
1921, doctors Frederick Banting and Charles Best found a approach of
removing the pancreas of many laboratory dogs to isolate the cells that make
conducting this trial, they would then attempt to produce pure insulin to
regulate human blood sugar levels.
(1) In Vice President for
Research of The Ohio State University, Alfred B. Garret''s 1963 book, The
Flash Genius, contributed that the exploration took the two doctors
ninety-two dogs to encounter the disease.
(2) In addition to the
experiment concluding that the removal of the pancreas diagnosed the dog with
diabetes, they also discovered that the dog's blood glucose level increased,
and its body weakened and dehydrated—explained by Montgomery.
(3) The reason for the
inclination of the blood glucose levels was a result of a molecule called
ketones; Linda Thrasybule, author of an September 2012 article, "People
Dying of Diabetes Who Never Knew They Had It, Study Finds"proclaimed that
"if ketone levels climb too high, they can poison the body, causing chemical
imbalances that can lead to coma, or death."
(4) Garrett stated, with
the use of the frozen combination of salt and water from the pancreas they've
discovered—both of the doctors were able to maintain the dog's blood
sugar level and making the dog gain a sufficient amount of weight which allowed
it to become stronger.
(5) However, due to the
inadequate supply of the extract, the dog's blood sugar levels skyrocketed,
leading to its death.
(6) The extract injected
into the dog was now called isletin.
(7) Due to the short supplies
of dog they had left, they needed to attain a rather larger supply of
pancreatic isletin; as a result they decided to obtain a larger amount of
supply of pancreas from a cow—said author, Garrett.
the following year of 1922, biochemist Bertram Collip made the powerful
change in purifying insulin.
(1) Both, Banting and
Collip injected the substance in their body; as a result, they experienced
their blood sugar levels declining, making them feel hungry and nauseated.
(2) The Chemical Heritage
Foundation, a headquarter of preserving the history of scientific
adventures, explained that victorious discovery led scientists to now focus on
their first patient who happened to be a young boy named Leonard Thompson.
(3) The child was on the
verge of death, but insulin saved his life—the injection was truly a
(4) Therefore, he was able
to live—regaining his weight and strength—informed by PBS
journalist, Dr. Howard Markel.
monumental legacy opened many doors for numerous scientists to spread the treatment
for human beings diagnosed with the deadly disease.
60 years, an even more purified form of insulin goes on the market worldwide by
the company, Eli Lilly.
(1) From that point on, they
marketed a newer type of insulin that would alter change in absorbing,
metabolising and excreting—as provided by the American Diabetes
(2) This new type was the
new trademark called Humalog.
(3) A vile that would also
nourish and sustain the many lives, including myself since
(transition: Now that I've discussed the
many significant findings of insulin in the 19th and 20th century, let's
finalize with the 21st century.)
III. The many vital
discoveries of insulin shed its light in the 21st century.
than constantly waiting to warm insulin for every syringe injection, the modern
era has now allowed diabetes to inject insulin through the touch of the insulin
pen and insulin pump.
convenience of having the two creates a platform for many diabetes individuals.
intake for both are quick and efficient; it's literally on the hip your
2015, doctor Edward Damiano created an invention called the iLet in
which the device is able to replicate a pancreas that can simultaneously
deliver insulin and glucagon every five minutes.
endocrinologist once educated me the function of a glucagon, it is an injection
to prevent my blood sugar from dropping.
a glucagon kit brings many responsibilities such as constantly carrying it
around my backpack and if I were to faint, it would cause severe problems not
only to myself but for loved ones as well.
expressed that having a pump that simultaneously injects insulin and glucagon
can benefit diabetes from controlling hypoglycemia—low blood sugar
levels, and hyperglycemia—high blood sugar levels.
company hopes to fulfill their test trial in 2017.
Signal the end: Before I end my
thought, I would like to remind you how insulin has improved throughout
Review main points: The significant
findings of insulin has strongly developed through the 19th, 20th, and 21st
Ending "kicker": Although insulin is only a temporary diabetic treatment, it has given me the opportunity to live longer with little pain and discomfort. I hope one day there will be a cure that can eliminate diabetes and change the world for the better. But as of right now, I have a close friend that will always stick by my side.
Association, American Diabetes."The History of a Wonderful Thing We Call Insulin" Diabetes Stops Here, 21 Aug. 2012, http://diabetesstopshere.org/2012/08/21/the-history-of-a-wonderful-thing-we-call-insulin/.
Bos, Carole. "Insulin -
A Life-Saving Discovery." AwesomeStories.Com, 19 Feb. 2014,
Centers for Disease
Control and Prevention. Diabetes: What's Insulin Resistance Got To Do with
It? | Features & Spotlights | Resources & Publications | Diabetes | CDC.
11 Oct. 2017, https://www.cdc.gov/diabetes/library/spotlights/diabetes-insulin-resistance.html.
University. "Functional Anatomy of the Endocrine Pancreas." Hypertexts for
15 Oct. 2017.
"Insulin Pump Affects Person's Quality of Life, Diabetes Study Shows." News-Medical.Net,
27 Mar. 2013,
Cells - What They Do, Role in Insulin.
http://www.diabetes.co.uk/body/beta-cells.html. Accessed 15 Oct. 2017.
Charles Best, James Collip, and John Macleod." Chemical Heritage Foundation,
1 June 2016, https://www.chemheritage.org/historical-profile/frederick-banting-charles-best-james-collip-and-john-macleod.
Garrett, Alfred Benjamin.
The Flash of Genius. Princeton, N.J., Van Nostrand, 1963.
Howard Markel. "How a
Boy Became the First to Beat Back Diabetes." PBS NewsHour, 11 Jan. 2013,
Landers, Mary. "THE PAST
AND FUTURE OF DIABETES: [HOME Edition]." Savannah Morning News; Savannah,
Ga., 13 Jan. 2000, p. 1B. ProQuest,
Mestel, Rosie. "Booster
Shots ROSIE MESTEL; Timeline Shows the Trials and Errors of Treating Diabetes:
[HOME EDITION]." Los Angeles Times; Los Angeles, Calif., 3 June 2002, p.
Montgomery, Bridget. From
Death to Life: The Discovery of Insulin. 24 Sept. 2017,
Nobel Lecture. Frederick
G. Banting - Nobel Lecture: Diabetes and Insulin. 15 Sept. 1925,
Petit, William A., and
Christine A. Adamec. The Encyclopedia of Diabetes. Facts on File, 2002.
Fankhauser. Pancreas and Islets of Langerhans — Science Learning Hub.
Rosie Cotter. "Big
Picture." Big Picture, https://bigpictureeducation.com/history-insulin.
Accessed 14 Oct. 2017.
THE MNT Editorial Team.
"The Discovery Of Insulin - How Was Insulin Discovered?" Medical News Today,
15 Oct. 2017.
The National Institute
of Diabetes and Digestive and Kidney Diseases, et al. "Prediabetes &
Insulin Resistance | NIDDK." National Institute of Diabetes and Digestive
and Kidney Diseases,
Accessed 14 Oct. 2017.
Thrasybule, Linda, et
al. "People Dying of Diabetes Who Never Knew They Had It, Study Finds." Live
Science, 27 Sept. 2012,
U.S National Library of
Medicine. Diabetes. https://medlineplus.gov/diabetes.html. Accessed 14
Vieira, Ginger. "Insulin for All: How Many Diabetics Are Without the Insulin They Need to Live" Diabetes Daily, 10 Nov. 2015, http://www.diabetesdaily.com/blog/2015/11/insulin-for-all-how-many-diabetics-are-without-insulin-they-need-to-live/.